What is this large polynucleated cell?
Unlike circulating tumor cells (CTCs), the cytokeratin stain (green) expression is smooth without a pattern.
Cancer Associated Macrophage-Like Cell (CAML) was named because of CD14 expression.
Very large: 25-300 microns in size
Markers and DNA of engulfed tumor material
Giant CAMLs are found in all major solid tumors and they appear in all stages of cancer
Examples of Giant CAMLs
Other cancer associated markers found in blood of cancer patients:
Circulating tumor cells (CTCs)
Circulating endothelial cells (CECs)
Epithelial mesenchymal transition cells (EMTs)
Circulating tumor DNA (ctDNA)
Circulating Tumor Cells (CTCs)
Found primarily in late stage breast, prostate and colorectal cancers
Cancerous nucleus morphology
CK 8, 18, 19 (+) with filamentous pattern
CK 8, 18, 19 fragmented into spots