Supporting Your Cancer Drug Development

Creatv Bio has developed a liquid biopsy test shown to effectively measure drug or vaccine response in subjects undergoing all types of treatment, including immunotherapy. The test captures cancer associated cells from the blood of cancer patients, and the most common cells are called Cancer Associated Macrophage-Like cells (CAMLs). This important test provides valuable information about cancer drug development in FDA Phase I-III clinical trials and can also be developed as a companion / complementary diagnostic (CDx).

Cancer Associated Cells

CAMLs are one of the most common stromal cells found in the blood of cancer patients and are present in all stages (I-IV). CAMLs are very large, ranging from 25 to 300 microns, and each cell exhibits unique morphological features. The blood test also provides information on Circulating Tumor Cells (CTCs), but CTCs are rare.

Examples of CAMLs

The most common tumor types we have tested

  • Breast
  • Lung
  • Melanoma
  • Kidney
  • Pancreatic
  • Ovarian
  • Renal
  • Prostate
  • Colon
  • Bladder
  • Endometrial
  • Liver
  • Sarcoma
  • H+N
View References
Infographic comparing the 10 most common cancers in the U.S. with detection rates of CAMLs in patient blood

Treatment Modalities

Creatv Bio has developed a liquid biopsy test shown to effectively measure drug or vaccine response in patients undergoing all types of treatment, including immunotherapy. The test captures cancer associated cells from the blood of cancer patients, and the most common cells are Circulating Tumor Cells (CTCs) and Cancer Associated Macrophage-Like cells (CAMLs).  This test provides valuable information for cancer drug development in FDA Phase I-III clinical trials and companion / complementary diagnostics (CDx) can be developed.

View References

Creatv Bio Supports Your CRO

Creatv Bio works seamlessly with your CRO to deliver quality specimen collection and data reporting to support your clinical trials. Creatv Bio’s biomarkers have been utilized in many FDA clinical trials. We will work closely with your CRO to complete the following steps:

Kit Preparation and Shipping

  • Special blood collection tubes
  • Specimen shipment and handling unstructions
  • Prepaid return label for samples

Results Reporting

  • Statistical analysis of results
  • CAML numbers and  size
  • CTC numbers
  • Customized markers
  • Serial draws recommended as per protocol
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